PUBLICATIONS

Leo Seballos, Nicole Richards, Daniel J. Stevens, Mira Patel, Laura Kapitzky, Scott Lokey, Glenn Millhauser and Jin Z. Zhang, Competitive binding effects on surface-enhanced Raman scattering of peptide molecules, Chemical Physics Letters, 447: 335-339, 2007.

Walter ED, Stevens DJ, Visconte MP, Millhauser GL., The Prion Protein is a Combined Zinc and Copper Binding Protein: Zn²⁺ Alters the Distribution of Cu²⁺ Coordination Modes, Journal of the American Chemical Society, in press.

Yu B, Millhauser GL., Chemical disulfide mapping identifies an inhibitor cystine knot in the agouti signaling protein, FEBS Letters, 581: 5561-65, 2007.

Candille SI, Kaelin CB, Cattanach BM, Yu B, Thompson DA, Nix MA, Kerns JA, Schmutz SM, Millhauser GL, Barsh GS., A {beta}-Defensin Mutation Causes Black Coat Color in Domestic Dogs, Science, 318: 1418-23, 2007.

Dong J, Bloom JD, Goncharov V, Chattopadhyay M, Millhauser GL, Lynn DG, Scheibel T, Lindquist S., Probing the Role of PrP Repeats in Conformational Conversion and Amyloid Assembly of Chimeric Yeast Prions, J. Biol. Chem. in press.

P. McCarthy, M. Chattopadhyay, G.L. Millhauser, N.V. Tsarevsky, L. Bombalski, K. Matyjaszewski, D. Shimmin, N. Avdalovic and C. Pohl, Nanoengineered analytical immobilized metal affinity chromatography stationary phase by atom transfer radical polymerization: Separation of synthetic prion peptides, Analytical Biochemistry, 366: 1-8, 2007.

Glenn L. Millhauser, Copper and the Prion Protein: Methods, Structures, Function and Disease, Annual Reviews of Physical Chemistry, 58: 299-320, 2007.

Pilgrim J. Jackson, Nick R. Douglas, Biaoxin Chai, Jonathan Binkley, Arend Sidow, Gregory S. Barsh and Glenn L. Millhauser, Structural and Molecular Evolutionary Analysis of Agouti and Agouti-Related Proteins, Chemistry & Biology, 13: 1297-1305, 2006.

Eric D. Walter, Madhuri Chattopadhyay and Glenn L. Millhauser, The Affinity of Copper Binding to the Prion Protein Octarepeat Domain: Evidence for Negative Cooperativity, Biochemistry, 45: 13083-13092, 2006.

Zalfa A. Abdel-Malek, Ana Luisa Kadekaro, Renny J. Kavanagh, Aleksandar Todorovic, Leonid N. Koikov, Joseph C. McNulty, Pilgrim J. Jackson, Glenn L. Millhauser, Sandy Schwemberger, George Babcock, Carrie Haskell-Luevano, James J. Knittel, Melanoma prevention strategy based on using tetrapeptide α-MSH analogs that protect human melanocytes from UV-induced DNA damage and cytotoxicity, FASEB Journal, 20: E888-E896, 2006.

Taha Rezai, Bin Yu, Glenn L. Millhauser, Matthew P. Jacobson, R. Scott Lokey, Cyclic peptide diastereomers differ markedly in their passive membrane diffusion rates: Testing the conformational hypothesis of membrane permeability, JACS, 128: 2510-2511, 2006.

Yung Seng Lee, Ben G. Challis, Darren A. Thompson , Giles S.H. Yeo, Julia M. Keogh, Michael E. Madonna, Vicki Wraight, David Meyre, Julian Hamilton-Shield, Christine Burren, Zala Ibrahim, Tim Cheetham, Peter Swift, AntheaBlackwood, Chiao-Chien Connie Hung, Nicholas J Wareham, Philippe Froguel, Stenvert Drop, Glenn L. Millhauser, Stephen O’Rahilly and I. Sadaf Farooqi, A Novel Mutation Implicates β-Melanocyte Stimulating Hormone in the Control of Human Energy Balance, Cell Metabolism, 3: 135-140, 2006.

Alistair J. Fielding, Stephen Fox, Glenn L. Millhauser, Madhuri Chattopadhyay, Peter M. H. Kroneck, G¸nter Fritz, Gareth R. Eaton and Sandra S. Eaton, Electron Spin Relaxation of Copper(II) Complexes in Glassy Solution between 10 and 120 K, Journal of Magnetic Resonance, 179: 78-90, 2006.

Glenn L. Millhauser, EPR Methods for Evaluating Copper Binding Sites in Prion and Other Partially Structured Proteins, in Protein Structures: Methods in Protein Structure and Stability Analysis, V. Uversky ed., Nova Science Publishers, Inc. NY in press.

Madhuri Chattopadhyay, Eric D. Walter, Dustin J. Newell, Pilgrim J. Jackson, Eliah Aronoff-Spencer, Jack Peisach, Gary J. Gerfen, Brian Bennett,William E. Antholine and Glenn L. Millhauser, The Octarepeat Domain of the Prion Protein Binds Cu(II) with Three Distinct Coordination Modes at pH 7.4, Journal of the American Chemical Society, 127: 12647-12656, 2005.

Pilgrim J. Jackson, Bin Yu, Benjamin Hunrichs, Darren A. Thompson , Biaoxin Chai, Ira Gantz & Glenn L. Millhauser, Chimeras of the Agouti-Related Protein: Insights into Agonist and Antagonist Selectivity of Melanocortin Receptors, Peptides, 26: 1978-1987, 2005.

Corine E. de Rijke, Pilgrim J. Jackson, Keith M. Garner, Rea J. van Rozen, Nick R. Douglas, Martien J.H. Kas, Glenn L. Millhauser and Roger A.H. Adan, Functional analysis of the Ala67Thr polymorphism in agouti related protein associated with anorexia nervosa and leanness, Biochemical Pharmacology, 70: 308-316, 2005

Joseph C. McNulty, Pilgrim J. Jackson, Darren A. Thompson, Biaoxin Chai, Ira Gantz, Gregory S. Barsh, Philip E. Dawson and Glenn L. Millhauser, Structures of the Agouti Signaling Protein, Journal of Molecular Biology, 346: 1059-1070, 2005.

Glenn L. Millhauser, Copper Binding in the Prion Protein, Accounts of Chemical Research, 37: 79-85, 2004.

Glenn L. Millhauser, Joe C. McNulty, Pilgrim Jackson, Darren Thompson, Gregory Barsh, Ira Gantz, Loops and Links: Structural Insights into the Remarkable Function of the Agouti-Related Protein, Annals of the New York Academy of Sciences, 994:27-35, 2003.

Colin S. Burns, Eliah Aronoff-Spencer, Guiseppe Legname, Stanley B. Prusiner, William E. Antholine, Gary J.  Gerfen, Jack Peisach and Glenn L. Millhauser, Copper Coordination in the Full-Length, Recombinant Prion Protein, Biochemistry, 42:6794-6803, 2003.

Biao-Xin Chai, Richard R. Neubig, Glenn L. Millhauser, Darren A. Thompson, Pilgrim J. Jackson, Gregory S. Barsh, Chris J. Dickinson, Ji-Yao Li, Yu-Mei Lae, Ira Gantz, Inverse Agonist Activity of Agouti and Agouti-related Protein, Peptides, 24:603-609, 2003.

Darren A. Thompson, Biao-Xin Chai, Hilary L.E. Rood, Michael A. Siani, Nicholai R. Douglas, Ira Gantz, and Glenn L. Millhauser, Peptoid Mimics of Agouti Related Protein, Bioorganic and Medicinal Chemistry Letters, 13: 1409 – 1413, 2003.

Joe C. McNulty, Darren A. Thompson, Michael R. Carrasco & Glenn L. Millhauser, Dap-SL: A New Site-Directed Nitroxide Spin Labeling Approach for Determining Structure and Motions in Synthesized Peptides and Proteins, FEBS Letters, 529:243-248, 2002.

Pilgrim J. Jackson, Joseph C. McNulty, Ying-Kui Yang, Darren A. Thompson, Biaoxin Chai, Ira Gantz, Gregory S. Barsh & Glenn L. Millhauser, Design, Pharmacology and NMR Structure of a Minimized Cystine Knot with Agouti-Related Protein Activity, Biochemistry, 41: 7565-7572, 2002.

Colin S. Burns, Eliah Aronoff-Spencer, Christine M. Dunham, Paula Lario, Nikolai I. Avdievich, William E. Antholine, Marilyn M. Olmstead, Alice Vrielink, Gary J. Gerfen, Jack Peisach, William G. Scott and Glenn L. Millhauser, Molecular Features of the Copper Binding Sites in the Octarepeat Domain of the Prion Protein, Biochemistry, 41:3991-4001, 2002.

Joseph C. McNulty, Darren A. Thompson, Kimberly A. Bolin, Jill Wilken, Gregory S. Barsh & Glenn L. Millhauser, High Resolution NMR Structure of the Chemically-Synthesized Melanocortin Receptor Binding Domain  AGRP(87 - 132) of the Agouti-Related Protein, Biochemistry, 40: 15520-15527, 2001.

A. D. Milov, Yu. D. Tsvetkov, F. Formaggio, M. Crisma, C. Toniolo, G. L. Millhauser, and J. Raap, Self-Assembling Properties of a Membrane-Modifying Lipopeptaibol in Weakly Polar Solvents Studied by CW ESR, J. Phys. Chem. B; 105: 11206-11213, 2001.

Joseph C. McNulty, Jennifer L. Silapie, Maia Carnevali, Christian T. Farrar, Robert G. Griffin, Fernando Formaggio, Marco Crisma, Claudio Toniolo and Glenn L. Millhauser, Electron Spin Resonance of TOAC Labeled Peptides: Folding Transitions and High Frequency Spectroscopy, Biopolymers, 55: 479-485, 2000.

Eliah Aronoff-Spencer, Colin S. Burns, Nikolai I. Avdievich, Gary J. Gerfen, Jack Peisach, William E. Antholine, Haydn L. Ball, Fred E. Cohen, Stanley B. Prusiner and Glenn L. Millhauser, Identification of the Cu²⁺ Binding Sites in the N-Terminal Domain of the Prion Protein by EPR and CD Spectroscopy, Biochemistry, 39:13760-13771, 2000.

Joseph C. McNulty and Glenn L. Millhauser, TOAC: The Rigid Nitroxide Side Chain, in Distance measurements in biological systems by EPR, L. Berliner, S. Eaton and G. Eaton editors, New York, London, Kluwer Academic/Plenum, 2000.

Alessandra Polese, D. Joe Anderson, Glenn Millhauser, Fernando Formagio, Marco Crisma, Fernando Marchiori and Claudio Toniolo, First Inter-Chain Peptide Interaction Detected by ESR in Fully Synthetic, Template-Assisted, Two-Helix Bundles, J. Am. Chem. Soc., 121:11071-11078, 1999.

Kimberly A. Bolin and Glenn L. Millhauser, α and 310: the Split Personality of Polypeptide Helices, Accounts of Chemical Research, 32:1027-1033, 1999.

D. Joe Anderson, Paul Hanson, Joe McNulty, Glenn Millhauser, Vania Monaco, Fernando Formaggio, Marco Crisma and Claudio Toniolo, Solution Structures of TOAC Labeled Trichogin GA IV Peptides from Conventional and Half Field Electron Spin Resonance, J. Am. Chem. Soc., 121:6919-6927, 1999.

M. Bennati, G. J. Gerfen, G. V. Martinez, R. G. Griffin, D. J. Singel and G. L. Millhauser, Nitroxide Side Chain Dynamics in a Spin Labeled Helix-Forming Peptide Revealed by High Frequency (139.5 GHz) EPR Spectroscopy, Journal of Magnetic Resonance, 139:281-286, 1999.

Vania Monaco, Fernando Formaggio, Marco Crisma, Claudio Toniolo, Paul Hanson and Glenn Millhauser, Orientation and Immersion Depth of a Helical Lipopeptaibol in Membranes Using TOAC as an ESR Probe, Biopolymers, 50:239-253, 1999.

Kimberly A. Bolin, D. Joe Anderson, Julie A. Trulson, Ira Gantz, Darren A. Thompson, Jill Wilken, Stephen B. H. Kent & Glenn L. Millhauser, NMR Structure of MinimizedHuman Agouti Related Protein prepared by total chemical synthesis, FEBS Letters, 451:125-131, 1999.

Julie A. Trulson and Glenn L. Millhauser, The Effect of Mutations on Peptide Models of the DNA Binding Helix of p53: Evidence for a Correlation Between Structure and Tumorigenesis, Biopolymers, 49: 215-224, 1999.

Vania Monaco, Fernando Formaggio, Marco Crisma, Claudio Toniolo, Paul Hanson, Glenn Millhauser, Clifford George, Jeffry R. Deschamps and Judith Flippen-Anderson, Determining the Occurrence of a 310-Helix and an α-Helix in Two Different Segments of a Lipopeptaibol Antibiotic Using TOAC, a Nitroxide Spin-Labeled Cα-Tetrasubstituted α-Aminoacid, Bioorganic and Medicinal Chemistry, 7: 119-131,1999.

Paul Hanson, D. Joe Anderson, Gary Martinez, Glenn Millhauser, Fernando Formaggio, Marco Crisma, Claudio Toniolo and Claudio Vita, ESR and Structural Analysis of Water Soluble, Alanine-Rich Peptides Incorporating TOAC, Mol. Phys., 95:957-966, 1998.

Gary V. Martinez and Glenn L. Millhauser, A Neural Network Approach to the Rapid Computation of Rotational Correlation Times from Slow Motional ESR Spectra, Journal of Magnetic Resonance,  134:124-130, 1998.

Kimberly A. Bolin, Paul Hanson, Sarah J. Wright and Glenn L. Millhauser, An NMR Investigation of the Conformational Effect of Nitroxide Spin Labels on Ala-rich Helical Peptides, Journal of Magnetic Resonance, 131:248-253, 1998.

Karen M. Lundberg, Chris Stenland, Fred E. Cohen, Stanley B. Prusiner and Glenn L. Millhauser, Kinetics and Mechanism of Amyloid Formation by the Prion Protein H1 Peptide as Determined by Time-Dependent ESR, Chemistry & Biology, 4:345-355, 1997.

Glenn L. Millhauser, Chris J. Stenland, Paul Hanson, Kimberly A. Bolin and Frank J. M. van de Ven, Estimating the Relative Populations of 310-Helix and α-Helix in Ala-Rich Peptides: A Hydrogen Exchange and High Field NMR Study, J. Molecular Biology, 267:963-974, 1997.

Glenn L. Millhauser, Chris J. Stenland, Kimberly A. Bolin and Frank J. M. van de Ven, Local Helix Content in an Alanine-Rich Peptide as Determined by the Complete Set of 3JHNα Coupling Constants, J. Biomolecular NMR, 7:331-334, 1996.

Paul Hanson, Glenn Millhauser, Fernando Formaggio, Marco Crisma and Claudio Toniolo, ESR Characterization of Hexameric, Helical Peptides Using Double TOAC Spin Labeling, J. Am. Chem. Soc, 118:7618-7625, 1996.

P. Hanson, G. Martinez, G. Millhauser, F. Formaggio, M. Crisma, C. Toniolo and C. Vita, Distinguishing Helix conformations in alanine-rich peptides using the unnatural amino acid TOAC and electron spin resonance, J. Am. Chem. Soc. 118:271-272, 1996.

G.L. Millhauser, Views of helical peptides: A proposal for the place of 310-helix along the thermodynamic folding pathway, Biochemistry, 34:3873-3877, 1995.

G.V. Martinez and G.L. Millhauser, FTIR spectroscopy of alanine-based peptides: Assignment of the amide I' modes for random coil and helix, J. Struct. Biology 114:23-27, 1995.

W.R. Fiori and G.L. Millhauser, Exploring the peptide 310-helix → α-helix equilibrium with double label electron spin resonance,  Biopolymers:Peptide Sci. 37:421-421, 1995.

Glenn L. Millhauser, S.M. Miick and W.R. Fiori, Electron spin labels, in Methods in Enzymology, K. Sauer ed., Academic Press, Orlando, Florida, 246: 589-610, 1995.

C. Toniolo, E. Valente, F. Formaggio, M. Crisma, G. Pilloni, C. Corvaja, A. Toffoletti, G.V. Martinez, M.P. Hanson, G.L. Millhauser, C. George, J.L. Flippen-Anderson, Synthesis and conformational studies of peptides containing TOAC, a spin labeled Cα,α-disubstituted glycine, J. Peptide Sci. 1: 45-57, 1994.

W.R. Fiori, K.M. Lundberg and G.L. Millhauser, A single carboxy-terminal arginine determines the amino-terminal helix conformation of an alanine-based peptide, Nature Structural Biology 1: 374-377, 1994.

S.M. Miick and G.L. Millhauser, Measuring Heisenberg spin exchange between spin labeled peptides with 2D ELDOR, J. Mag. Res. Series B 104B: 81-84, 1994.

W.R. Fiori and G.L. Millhauser, Increasing sequence length favors α-helix over 310-helix in alanine-based peptides: Evidence for a length-dependent structural transition, accelerated publication in Biochemistry 32: 11957-11962, 1993.

S.M. Miick, K.M. Casteel and G.L. Millhauser, Experimental molecular dynamics of an alanine-based helical peptide determined by spin label electron spin resonance, Biochemistry 32: 8014-8021, 1993.

L.J. Calciano, W.A. Escobar, G.L. Millhauser, S.M. Miick, J. Rubaloff, A.P. Todd and A.L. Fink, Side-chain mobility of the β-Lactamase A state probed by ESR, Biochemistry 32: 5644-5649, 1993.

G.L. Millhauser, Site-selective placement of ESR spin labels: New structural methods for peptides and proteins, Trends Biochem. Sci. 17:448-452, 1992.

S.M. Miick, G.V. Martinez, W.R. Fiori, A.P. Todd and G.L. Millhauser, Short alanine-based peptides may form 310-helices and not α-helices in aqueous solution, Nature 359: 653-655, 1992.

S.M. Miick and G.L. Millhauser, Rotational diffusion and intermolecular collisions of a spin labeled α-helical peptide determined by electron spin echo spectroscopy, Biophys. J. 63: 917-925, 1992.

S.M. Miick, A.P. Todd and G.L. Millhauser, Position-dependent local motions in spin labeled analogs of a short α-helical peptide determined by electron spin resonance, Biochemistry 30: 9498-9503,1991.

A.P. Todd and G.L. Millhauser, ESR spectra reflect local and global mobility in a short spin-labeled peptide throughout the α-helix → coil transition, Biochemistry 30: 5515-5523, 1991.

R.E. Oswald, G.L. Millhauser and A.A. Carter, Diffusion model of ion channel gating: Extension to agonist-activated ion channels, Biophys. J. 59: 1136-1142, 1991.

J. Gorcester, G.L. Millhauser and J.H. Freed, Two-dimensional electron spin resonance, in Modern Pulsed and Continuous-Wave Electron Spin Resonance,  L. Kevan and M.K. Bowman eds., Wiley, New York, 1990.

G.L. Millhauser, Reptation theory of ion channel gating, Biophys. J. 57: 857-864, 1990.

J. Gorcester, G.L. Millhauser and J.H. Freed, Two-dimensional and Fourier transform EPR, in Advanced EPR in Biology and Biochemistry,  A.J. Hoff ed., Elsevier, Amsterdam, 1989.

G.L. Millhauser, A.A. Carter, D.J. Schneider, J.H. Freed and R.E. Oswald, Rapid singular value decomposition for time-domain analysis of magnetic resonance signals by use of the Lanczos algorithm, J. Mag. Res., 82: 150-155, 1989.

G.L. Millhauser, E.E. Salpeter and R.E. Oswald, Rate-amplitude correlation from single-channel records: A hidden structure in ion channel gating kinetics?, Biophys. J., 54: 1165-1168, 1988.

G.L. Millhauser, E.E. Salpeter and R.E. Oswald, Diffusion models of ion channel gating and the origin of power law distributions from single-channel recording, Proc. Natl. Acad. Sci., 85: 1503-1507, 1988.

G.L. Millhauser and R.E. Oswald, A reevaluation of the mathematical models for simulating single-channel and whole-cell ionic currents, Synapse, 2: 97-103, 1988.

R.L. Papke, G.L. Millhauser, Z. Lieberman and R.E. Oswald, Relationships of agonist properties to the single channel kinetics of nicotinic acetylcholine receptors, Biophys. J., 53: 1-10, 1988.

G.L. Millhauser, J. Gorcester and J.H. Freed, New time-domain EPR methods for the study of slow motion on surfaces, in Electronic Magnetic Resonance of the Solid State,  J. Weil ed., Canadian Society Chemistry, Ottawa, 1987.

P.S. Skerker, R.R. Miller, G.L. Millhauser and D.S. Clark, Structural and functional responses of enzymes to immobilization: new insights from EPR spectroscopy, Enzyme Engineering 8, Ann. N.Y. Acad. Sci., 501: 80-84, 1987.

F. Wise, M.J. Rosker, G.L. Millhauser and C.L. Tang, Application of linear prediction least- squares fitting to time-resolved optical spectroscopy, IEEE J. Quantum Electron., QE-23:1116-1121, 1987.

G.L. Millhauser and J.H. Freed, Linear prediction and resolution enhancement of complex line shapes in two-dimensional electron-spin-echo spectroscopy, J. Chem. Phys., 85: 63-67, 1986.

L.J. Schwartz, G.L. Millhauser and J.H. Freed, Two-dimensional electron spin echos: magnetization transfer and molecular dynamics, Chem. Phys. Lett., 127: 60-66, 1986.

G.A. Marg, G.L. Millhauser, P.S. Skerker and D.S. Clark, Application of EPR methods in studies of immobilized enzyme systems, Biochemical Engineering 4, Ann. N.Y. Acad. Sci., 469: 253-258, 1986.

H. Goldwhite, J. Kaminski, G. Millhauser, J. Ortiz, M. Vargas, L. Vertal, M. Lappert and S. Smith, Phosphorus-Phosphorus Single or Double Bond Formation from PCl3-nRn (n=1 or 2) and a Bis-Imidazolidine Reducing Agent, J. Organomett. Chem., 301: 21-25, 1986.

G.L. Millhauser and J.H. Freed, Two-dimensional electron spin echo spectroscopy and slow motions, J. Chem. Phys., 81: 37-48, 1984.

L. Kar,  G.L. Millhauser and J.H. Freed, Detection of slow motions in oriented lipid multilayers by two-dimensional electron echo spectroscopy, J. Phys. Chem., 88: 3951-3956, 1984.

C.J. Page, G.L. Millhauser, P.P. Edwards, J.H. Freed and M.J. Sienko, Electron spin echo studies of relaxation times in lithium-methylamine solutions, J. Phys. Chem., 88: 3785-3789, 1984.

J.F. Gerlits, H. Goldwhite, I. Gargurevich, R.T. Keys, G. Millhauser, and L.E. Vertal, Bulky alkyls and amides of main group 5 elements:  Part III.  Effects of bulky substituents on the dissociation of main group 5 compounds as measured by EPR, Bull. Mag. Res., 2: 210-211, 1980.

C. Takimoto, G. Siwapinyoyos, K. Fuller, A.P., Fung, L. Liauw, W. Jarvis, G. Millhauser, and T. Onak, A study on the preparation and rearrangement of the halogenated closo-carboranes ClnC2B4H6-n (n=1,2) and ClnC2B5H7-n (n=1,2), Inorg. Chem., 19: 107-110, 1980.