Office: 127 Sinsheimer Labs
Phone: 831-459-4251
Fax: 831-459-2935
Email: pradip@chemistry.ucsc.edu

• NO-Donor project:

M. J. Rose, M. M. Olmstead and P. K. Mascharak, Photosensitization via Dye Coordination: A new Strategy to Synthesize Metal Nitrosyls that Release NO under Visible Light, J. Am. Chem. Soc. 2007, In Press.

M. J. Rose, A. K. Patra, E. A. Alcid, M. M. Olmsted and P. K. Mascharak, Ruthenium Nitrosyls Derived from Polypyridine Ligands with Carboxamide or Imine Nitrogen Donor(s): Isoelectronic Complexes with Different NO Photolability. Inorganic Chemistry, 2007, 46, 2328-2338.

M. Madhani, A. K. Patra, T. W. Miller, A. A. Eroy-Reveles, A. Hobbs, J. M. Fukuto and P. K. Mascharak, Biological Activity of Designed Photolabile Nitrosyls: Light-Dependent Activation of Soluble Guanylate Cyclase and Vasorelaxant Properties in Rat Aorta. J. Med. Chem. 2006, 49, 7325-7330.

I. Szundi, M. Rose, I. Sen, A. A. Eroy-Reveles, P. Mascharak and O. Einarsdottir, A New Approach for Studying Fast Biological Reactions Involving Nitric Oxide: Generation of NO Using Photolabile Ruthenium and Manganese NO Donors. Photochem. Photobiol. 2006, 82, 1377-1384.

A. A. Eroy-Reveles, Y. Leung and P. K. Mascharak, Release of Nitric oxide from a Sol-gel Hybrid Material Containing a Photoactive Manganese Nitrosyl upon Illumination with Visible Light. J. Am. Chem. Soc. 2006, 128, 7166-7167.

R. Afshar, A. K. Patra, E. Bill, M. M. Olmstead and P. K. Mascharak, Synthesis, Structure, and Properties of an Fe(II) Carbonyl [(PaPy3)Fe(CO)](ClO4): Insight into the Reactivity of Fe(II)-CO and Fe(II)-NO Moieties in Non-heme Iron Chelates of N-donor Ligands. Inorg. Chem. 2006, 45, 3774-3781.

R. K. Afshar, A. K. Patra and P. K. Mascharak, Light-Induced Inhibition of Papain by a {Mn-NO}6 Nitrosyl: Identification of Papain-SNO Adduct by Mass Spectrometry. J. Inorg. Biochem. 2005, 99, 1458-1464.

R. K. Afshar, A. K. Patra, M. M. Olmstead and P. K. Mascharak, Syntheses, Structures and Reactivities of {Fe-NO}6 Nitrosyls Derived from Polypyridine-Carboxamide Ligands: Photoactive NO-donors and Reagents for S-nitrosylation of Alkyl Thiols. Inorg. Chem. 2004, 43, 5736-5743.

A. K. Patra, M. J. Rose, K. Murphy, M. M. Olmstead and P. K. Mascharak, Photolabile Ruthenium Nitrosyls with Planar Dicarboxamide Tetradentate N4 Ligands: Effects of In-plane and Axial Ligand Strength on NO Release. Inorg. Chem. 2004, 43, 4487-4495.

A. K. Patra, M. J. Rose, M. M. Olmstead and P. K. Mascharak, Reactions of Nitric Oxide with a Low-Spin Fe(III) Center Ligated to a Tetradentate Dicarboxamide N4 Ligand: Parallels between Heme and Non-Heme Systems. J. Am. Chem. Soc. 2004, 126, 4780-4781.

K. Ghosh, A. A. Eroy-Reveles, T. R. Holman, M. M. Olmstead and P. K. Mascharak, Reactions of NO with Mn(II) and Mn(III) Center Coordinated to Carboxamido Nitrogen: Synthesis of a Manganese Nitrosyl with Photolabile NO. Inorg. Chem. 2004, 43, 2988-2997.

A. K. Patra, M. M. Olmstead and P. K. Mascharak, A Ruthenium Nitrosyl That Delivers NO to Proteins in Aqueous Solution Upon Short Exposure to UV Light. Inorg. Chem. 2003, 42, 7363-7365.

A. K. Patra, J. M. Rowland, D. S. Marlin, E. Bill, M. M. Olmstead and P. K. Mascharak, Iron-nitrosyls of a Pentadentate Ligand Containing a Single Carboxamide Group: Syntheses, Structures, Electronic Properties and Photolability of NO. Inorg. Chem. 2003, 42, 6812-6823.

A. K. Patra, R. Afshar, M. M. Olmstead and P. K. Mascharak, The First Non-Heme Iron(III) Complex with Ligated Carboxamido Group that Exhibits Photolability of Bound NO Ligand. Angew. Chem. Intl. Ed. Eng. 2002, 41, 2512-2515.

• Enzyme Modeling Project:
  

Nitrile Hydratase

T. C. Harrop, M. M. Olmstead and P. K. Mascharak, Modeling the Active Site of Nitrile Hydratase: Synthetic Strategies to Ensure Simulataneous Coordination of Carboxamido-N and Thiolato-S to Fe(III) Centers. Inorg. Chem. 2005, 44, 9527-9533.

T. C. Harrop and P. K. Mascharak, Fe(III) and Co(III) Centers with Carboxamido Nitrogen and Modified Sulfur Coordination: Lessons Learned from Nitrile Hydratase. Acc. Chem. Res. 2004, 37, 253-260.

L. A. Tyler, J. C. Noveron, M. M. Olmstead and P. K. Mascharak, Modulation of the pKa of metal-bound Water Via Oxidation of Thiolato Sulfur in Model Complexes of Co(III)-Containing Nitrile Hydratase: Insight into Possible Effect of Cysteine Oxidation in Co-Nitrile Hydratase. Inorg. Chem. 2003, 42, 5751-5761.

P.K. Mascharak, Structural and Functional Models of Nitrile Hydratase. Coord. Chem. Rev. 2002, 225, 201-214.

J. C. Noveron, M. M. Olmstead and P. K. Mascharak, A Synthetic Analogue of the Active site of Fe-containing Nitrile Hydratase with Carboxamido N and Thiolato S as Donors: Synthesis, Structure and Reactivities. J. Am. Chem. Soc. 2001, 123, 3247-3259.

Acetyl CoA Synthase/CO Dehydrogenase

T. C. Harrop, M. M. Olmstead and P. K. Mascharak, Synthetic Analogues of the Active Site of the A-Cluster of Acetyl Coenzyme A Synthase/CO Dehydrogenase: Syntheses, Structures, and Reactions with CO. Inorg. Chem. 2006, 45, 3424-3436.

T. C. Harrop and P. K. Mascharak, Structural and Spectroscopic Models of the A-Cluster of Acetyl Coenzyme A Synthase/Carbon Monoxide Dehydrogenase: Nature’s Monsanto Acetic Acid Catalyst. Coord. Chem Rev. 2005, 249, 3007-3024.

T. C. Harrop, M. M. Olmstead and P. K. Mascharak, Structural Models of the Bimetallic Subunit at the A-Cluster of Acetyl Coenzyme A Synthase/CO Dehydrogenase: Binuclear Sulfur-Bridged Ni-Cu and Ni-Ni Complexes and Their Reactions with CO. J. Am. Chem. Soc. 2004, 126, 14714-14715.

T. C. Harrop, M. M. Olmstead and P. K. Mascharak, Binding of CO to Structural Models of the Bimetallic Subunit at the A-Cluster of Acetyl Coenzyme A Synthase/CO Dehydrogenase. J. Chem. Soc. Chem. Commun. 2004, 1744-1745.

 

• Designed Catalyst project:

  R. K. Afshar, A. A. Eroy-reveles, M. M. Olmstead and P. K. Mascharak, Stoichiometric and Catalytic Secondary O-Atom Transfer by Fe(III)-NO2 Complexes Derived from a Planar Tetradentate Non-Heme Ligand: Reminiscence of Heme Chemistry. Inorganic Chemistry, 2006, 45, 10347-10354.

  A. K. Patra, R. K. Afshar, J. M. Rowland, M. M. Olmstead and P. K. Mascharak, Thermally-Induced Stoichiometric and Catalytic O Atom Transfer by a Non-heme Iron(III)-Nitro Complex: First Example of reversible {Fe-NO}7 FeIII-NO2 Transformation in presence of Dioxygen. Angew. Chem. Intl. Ed. Eng. 2003, 42, 4517-4521.

  T. C. Harrop, M. M. Olmstead and P. K. Mascharak, Dioxygen Activation by a Dinuclear Nickel Thiolate Complex: Structural Characterization of the Ligand Oxidized Product. J. Chem. Soc. Chem. Commun. 2003, 410-411.

  J. M. Rowland, M. M. Olmstead and P. K. Mascharak, Syntheses, Structures, and Reactivity of Low Spin Iron(III) Complexes Containing a Single Carboxamido Nitrogen in a [FeN5L] Chromophore. Inorg. Chem. 2001, 40, 2810-2817.

  F. A. Chavez and P. K. Mascharak, Structure-Reactivity Correlations in Cobalt(III)-Alkylperoxo Complexes and Their Role in Cobalt-Catalyzed Oxidation of Hydrocarbons. Acc. Chem. Res. 2000, 33, 539-545.

• Complete List of Publications