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   Recent Publications

  1. Rubio, B. K.; Robinsion, S. J.; Avalos, C. E.; Valeriote, F. A.; de Voogd, N. J.; Crews, P. “Revisiting the Sponge Sources, Stereostructure, and Biological Activity of Cyclocinamide A.” J. Nat. Prod. 2008. (in press)

  2. Boot, C. M.; Gassner, N. C.; Compton, J. E.; Tenney, K.; Tamble, C. M.; Lokey, S.; Holman, T. R.; Crews, P. "Pinpointing Pseurotins from a Marine-Derived Aspergillus as Tools for Chemical Genetics Using a Synthetic Lethality Yeast Screen." J. Nat. Prod. 2007, 70, 1671-1675.

  3. Deschamps, J. D.; Gautschi, J. T.; Whitman, S.; Johnson, T. A.; Gassner, N. C.; Crews, P.; Holman, T. R. "Discovery of platelet-type 12-human lipoxygenase selective inhibitors by high-throughput screening of structurally diverse libraries. Bioorg. Med. Chem. 2007, 15, 6900-6908.

  4. Boot, C. M.; Amagata, T.; Tenney, K.; Compton, J. E.; Pietraszkiewicz, H.; Valeriote, F, A.; Crews, P. "Four Classes of Structurally Unusual Peptides from two Marine Derived Fungi: Structures and Bioactivities." Tetrahedron 2007, 63, 9903-9914.

  5. Johnson, T. A.; Tenney, K.; Cichewicz, R. H.; Morinaka, B.; White, K. N.; Amagata, T.; Subramanian, B.; Media, J,; Mooberry, S. L.; Valeriote, F. A.; Crews, P. "Sponge-Derived Fijianolides Polyketide Class: Further Evaluation of their Structural and Cytotoxicity Properties." J. Med. Chem. 2007, 50, 3795-3803.

  6. Hu, X.; Dang, Y.; Tenney, K.; Crews, P.; Tsai, C. W.; Sixt, D. M.; Cole, P. A.; Liu, J. O. "Regulation of c-Scr Non-receptor Tyrosine Kinase Activity by Bengamide A through Inhibition of Metionine Aminopeptidases." Chem. Biol. 2007, 14, 764-774.

  7. Robinson, S. J.; Tenney, K.; Yee, D.; Martinez, L; Media, J. E.; Valeriote, F. A.; van Soest, R. W. M.; Crews, P. "Probing the Bioactive Constituents from Chemotypes of the Sponge Psammocinia aff. bulbosa." J. Nat. Prod. 2007, 70, 1002-1009.

  8. Li, H.; Amagata, T.; Tenney, K.; Crews, P. "Additional Scalarane Sesterterpenes from the Sponge Phyllospongia papyracea." J. Nat. Prod. 2007, 70, 802-807.

  9. Rubio, B. K.; van Soest, R. W. M.; Crews, P. "Extending the Record of Meroditerpenes from Cacospongia Marine Sponges." J. Nat. Prod. 2007, 70, 628-631.

  10. Piña, I. C.; White, K. N.; Cabrera, G.; Rivero, E.; Crews, P. "Bromopyrrole Carboxamide Biosynthetic Products from the Caribbean Sponge Agelas dispar." J. Nat. Prod. 2007, 70, 613-617.

  11. Gassner, N. C.; Tamble, C. M.; Bock, J. E.; Cotton, N.; White, K. W.; Tenney, K.; St. Onge, R. P.; Proctor, M. J.; Giaever, G.; Davis, R. W.; Crews, P.; Holman, T. R.; Lokey, R. S.  "Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay." J. Nat. Prod. 2007, 70, 383-390.

  12. Gautschi, J. T.; Tenney, K.; Compton, J.; Crews, P. "Chemical Investigations of a Deep Water Marine Derived Fungus: Simple Amino Acid Derivatives from an Arthrinium sp." Nat. Prod. Comm. 2007, 2, 1-6.

  13. Ralifo, P.; Sanchez, L.; Gassner, N. C.; Tenney, K.; Lokey, T. S.; Holman, T. R.; Valeriote, F. A.; Crews, P. "Pyrroloacridine Alkaloids from Plakortis quasiamphiaster: Structures and Bioactivity." J. Nat. Prod. 2007, 70, 95-99.

  14. Wegerski, C. J.; Hammond, J.; Tenney, K.; Matainaho, T.; Crews, P. "A Serendipitous Discovery of Isomotuporin-Containing Sponge Populations of Theonella swinhoei." J. Nat. Prod. 2007, 70, 89-94.

  15. Ralifo, P.; Tenney, K.; Valeriote, F. A.; Crews, P. "A Distinctive Structural Twist in the Aminoimidazole Alkaloids from a Calcareous Marine Sponge: Isolation and Characterization of Leucosolenamenes A and B." J. Nat. Prod. 2007, 70, 33-38.

  16. Amagata, T.; Morinaka, B. I.; Amagata, A.; Tenney, K.; Valeriote, F. A.; Lobkobsky, E.; Clardy, J.; Crews, P. "A Chemical Study of Cyclic Depsipeptides Produced by a Sponge-Derived fungus." J. Nat. Prod. 2006, 69, 1560-1565.

  17. Wegerski, C. J.; Sonnenschein, R. N.; Cabriales, F.; Valeriote, F. A.; Matainago, T.; Crews. P. "Stereochemical Challenges in Characterizing Nitrogenous Spiro-Axane Sesquiterpenes fromthe Indo-Pacific Sponges Amorphinopsis and Axinyssa." Tetrahedron 2006, 62, 10393-10399.

  18. Sonnenschein, R. N.; Johnson, T. A.; Tenney, K.; Valeriote, F. A.; Crews, P. "A Reassignment of (-)-Mycothiazole and the Isolation of a Related Diol." J. Nat. Prod. 2006, 69, 145-147

  19. Subramanian, B.; Nakeff, A.; Tenney, K.; Crews, P.; Gunatilaka, L.; Valeriote, F. "A New Paradigm for the Development of Anticancer Agents from Natural Products." Journal of Experimental Therapeutics and Oncology. 2006, 5, 195-204.

  20. Boot, C. M.; Tenney, K.; Valeriote, F. A.; Crews, P. "Highly N-methylated LInear Peptides Produced by an Atypical Sponge-Derived Acremonium sp." J. Nat. Prod. 2006, 69, 83-92.

  21. Christian, O. E.; Compton, J.; Christian, K. R.; Mooberry, S. L.; Valeriote, F. A.; Crews, P. "Using Jasplakinolide to Turn on Pathways that Enable the Isolation of New Chaetoglobosins from Phomopsis asparagi." J. Nat. Prod. 2005, 68, 1592-1597.

  22. Segraves, N. L.; Crews, P. "Invesigation of Brominated Tryptophan Alkaloids from Two Thorectidae Sponges: Thorectandra and Smenospongia." J. Nat. Prod. 2005, 68, 1484-1488.

  23. Cichewicz, R. H.; Clifford, L. J.; Lassesn, P. R.; Cao, X.; Freedman, T. B.; Nafie, L. A.; Deschamps, J. D.; Kenyon, V. A.; Flanary, J. R.; Holman, T. R.; Crews, P. "Stereochemical Determination and Bioactivity Assessment of (S)-(+)-Curcuphenol Dimers Isolated from the Marine Sponge Didiscus aceratus and Synthesized through Laccase Biocatalysis." Bio. Med. Chem. 2005, 13, 5600-5612.

  24. Segraves, N. L.; Crews, P. "A Madagascar Sponge Batzella sp. as a Source of  Alkylated Iminosugars." J. Nat. Prod. 2005, 68, 118-121.

  25.  Ralifo. P; Crews, P. "A New Structural Theme in the Imidazole Containing Alkaloids from a Calcareous Leucetta Sponge". J. Org. Chem. 2004, 69, 9025-9029.                                   

  26.  Cichewicz, R. H.; Kenyon, V. A.; Whitman, S.; Morales, N. M.; Arguello, J. F.; Holman, T. R.; Crews, P. "Redox Inactivation of Human 15-Lipoxygenase by Marine-Derived Meroditerpenes and Synthetic Chromanes:  Archetypes for a Unique Class of Selective and Recyclable   Inhibitors". J. Am. Chem. Soc. 2004, 126, 14910-14920.   

  27. Wegerski, C. J.; France, D.; Cornell-Kennon, S.; Crews, P. "Using a Kinase Screen to Investigate the Constituents of the Sponge Stelleta clavosa Obtained from Diverse Habitats". Bioorg. Med. Chem. 2004, 12, 5631-5637.

  28. Segraves, E. N.; Shah, R. R.; Segraves, N. L.; Johnson, T. A.; Whitman, S.; Sui, J. K.; Kenyon, V. A.; Cichewicz, R. H.; Crews, P.; Holman, T. R. "Probing the Activity Differences of Simple and Complex Brominated Aryl Compounds against 15-Soybean, 15-Human and 12-Human Lipoxygenases". J. Med. Chem. 2004, 47, 4060-4065.

  29. Gautschi, J. T.; Whitman, S.; Holman, T. R.; Crews, P. "An Analysis of Phakellin and Oroidin Structures Stimulated by Further Study of an Agelas Sponge". J. Nat. Prod. 2004, 67, 1256-1261.

  30.  Vilozny, B.; Amagata, T.; Mooberry, S. L.; Crews, P. "A New Dimension to the Biosynthetic Products Isolated from the Sponge Negombata magnifica". J. Nat. Prod. 2004, 67, 1055-1057.

  31.  Cichewicz, R. H.; Valeriote, F. A.; Crews, P. "Psymberin, A Potent Sponge- Derived Cytotoxin from Psammocinia Distantly Related to the Pederin Family". Org. Lett. 2004, 6, 1951-1954.

  32.  Segraves, N. L.; Robinson, S. J.; Garcia, D.; Said, S. A.; Fu, X.; Schmitz, F. J.; Petraszkiewicz, H.; Valeriote, F. A.; Crews, P. "Comparison of Fascaplysin and Related Alkaloids – A Study of Structures, Cytotoxicities, and Sources". J. Nat. Prod. 2004, 67, 783-792.

  33.  Gautschi, J. T.; Amagata, T.; Amagata, A.; Valeriote, F. A.; Mooberry, S. L.; Crews, P. "Expanding the Strategies in Natural Product Studies of Marine-Derived Fungi: A Chemical Investigation of Penicillium Obtained from Deep Water Sediment". J. Nat. Prod. 2004, 67, 362-367.

  34.  Sonnenschein, R. N.; Farias, J. J.; Tenney, K.; Mooberry, S. L.; Lobkovsky, E.; Clardy, J.; Crews, P. "A Further Study of the Cytotoxic Constituents of a Milnamide Producing Sponge". Org. Lett. 2004, 6, 779-782.

  35.  Lepourcelet, M.; Chen, Y.-N. P.; France, D. S.; Wang, H.; Crews, P.; Petersen, F.; Bruseo, C.; Wood, A. W.; Shivdasani, R. "A. Small-Molecule Antagonists of the Oncogenic Tcf/b-Catenin Protein Complex". Cancer Cell 2004, 5, 91-102.

  36.  Crews, P.; Gerwick, W. H.; Schmitz, F. J.; France, D.; Bair, K. W.; Wright, A. E.; Hallock, Y. "Molecular Approaches to Discover Marine Natural Product Anticancer Leads – An Update from a Drug Discovery Group Collaboration". Pharm. Biol. 2003, 41, 39-52.

  37.  Amagata, T.; Amagata, A.; Tenney, K.; Valeriote, F. A.; Lobkovsky, E.; Clardy, J.; Crews, P. "Unusual C25 Steroids Produced by a Sponge-Derived Penicillium citrinum". Org. Lett. 2003, 5, 4393-4396.

  38. Amagata, T.; Rath, C.; Rigot, J. F.; Tarlov, N.; Tenney, K.; Valeriote, F. A.; Crews, P. "Structures and Cytotoxic Properties of Trichoverroids and their Macrolide Analogues Produced by Saltwater Culture of Myrothecium verrucaria". J. Med. Chem. 2003, 46, 4342-4350.

  39. Edrada, R. A.; Stessman, C. C.; Crews, P. "Uniquely Modified Imidazole Alkaloids from a Calcareous Leucetta Sponge". J. Nat. Prod. 2003, 66, 939-942.

  40. Wenzel, P. J.; Crews, P. "Probing Biotransformation Relationships Among Pyridoacridines by Focusing on Oxygenated Analogs". J. Nat. Prod. 2003, 66, 873-875.

  41. Piña, I. C.; Gautschi, J. T.; Wang, G.-Y.-S.; Sanders, M. L.; Schmitz, F. J.; France, D.; Cornell-Kennon, S.; Sambucetti, L. C.; Remiszewski, S. W.; Bair, K. W.; Crews, P. "Psammaplins from the Sponge Psuedoceratina purpurea: Inhibition of Both Histone Deacetylase and DNA Methyltransferase". J. Org. Chem. 2003, 68, 3866-3873.

  42. Segraves, N. L.; Lopez, S.; Johnson, T. A.; Said, S. A.; Fu, X.; Schmitz, F. J.; Pietraszkiewicz, H.; Valeriote, F. A.; Crews, P. "Structures and Cytotoxicities of Fascaplysin and Related Alkaloids from Two Marine Phyla - Fascaplysinopsis Sponges and Didemnum Tunicates". Tetrahedron Lett. 2003, 44, 3471-3475.

  43. Amagata, T.; Whitman, S.; Johnson, T. A.; Stessman, C. C.; Loo, C.; Lobkovsky, E.; Clardy, J.; Crews, P.; Holman, T. R. "Explored Sponge-Derived Terpenoids for their Potency and Selectivity Against 12-Human, 15-Human, and 15-Soybean Lipoxygenases". J. Nat. Prod. 2003, 66, 230-235.

  44. Crews, P.; Clark, D. P.; Tenney, K. "Variation in the Alkaloids Among Indo-Pacific Leucetta Sponges". J. Nat. Prod. 2003, 66, 177-182.

  45. Piña, I. C.; Sanders, M. L.; Crews, P. "Puupehenone Congeners from an Indo- Pacific Hyrtios Sponge". J. Nat. Prod. 2003, 66, 2-6.

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