Here is a selection of our recent publications.
van Leyen, K., Arai, K., Jin, G., Kenyon, V., Gerstner, B., Rosenberg, P.A., Holman, T.R., Lo, E.H., "Novel lipoxygenase inhibitors as neuroprotective reagents", J Neurosci Res., 86, 904-909, 2008 . PDF
Thompson, A., Reddi, A.R., Shi, X., Goldbeck, R., Moenne-Loccoz, P., Gibney, B.R., Holman, T.R., " Measurement of the Heme Affinity for Yeast Dap1p, and Its Importance in Cellular Function", Biochemistry, 46, 14629-14637, 2007. PDF
Boot, C.M., Gassner, N. C., Compton, J.E., Tenney, K., Tamble, C.M., Lokey, R. S., Holman, T. R., Crews, P. "Pinpointing Pseurotins from a Marine-Derived Aspergillus as Tools for Chemical Genetics Using a Synthetic Lethality Yeast Screen", J Nat Prod, 70, 1672-1675, 2007. PDF
Vasquez-Martinez, Y., Ohri, R.V., Kenyon, V., Holman, T.R., Sepulveda-Boza, "Structure-Activity Relationship Studies of Flavonoids as Potent Inhibitors of Human 12-LO, 15-LO-1 and 15-LO-2", Bio. Med. Chem., 15, 7408-7425, 2007. PDF
Deschamps, J., Gautschi, J.T., Whitman, S., Johnson, T.A., Gassner, N.C., Crews, P., Holman, T.R., "Discovery of 12-hLO Selective Inhibitors by HTP Screening of Structurally Diverse Libraries", Bio. Med. Chem., 15, 6900-6908, 2007. PDF
Neidig, M., Wecksler, A., Schenk, G., Holman, T.R., Solomon, E. "Kinetic and Spectroscopic Studies N694C Lipoxygenase: A Probe of the Substrate Activation Mechanism of a Non-Heme Ferric Enzyme", J.A.C.S., 129, 7531-7537, 2007. PDF
Gassner, N., Tamble, C., Bock, J., Cotton, N., White, K., Tenney, K., Onge, R., Proctor, M., Giaever, G., Davis, R., Crews, P., Holman, T. R., Lokey, R. S. "Accelerating the Discovery of Biologically Active Small Molecules Using a High-Throughput Yeast Halo Assay", J Nat Prod, 70, 383-390, 2007. PDF
Ralifo, P., Sanchez, L., Gassner, N. C., Tenney, K., Lokey, R. S., Holman, T. R., Valeriote, F. A., Crews, P. "Pyrroloacridine alkaloids from Plakortis quasiamphiaster: structures and bioactivity", J Nat Prod, 70, 95-9, 2007 . PDF
Segraves, E., Chruszcz, M., Neidig, M.,Ruddat, V., Zhou, J., Wecksler, A., Minor, W., Solomon, E., Holman, T.R. "Kinetic, Spectroscopic, and Structural Investigations of the Soybean Lipoxygenase-1 First-Coordination Sphere Mutant, Asn694Gly", Biochemistry, 45, 10233-10242, 2006. PDF
Deschamps, J., Kenyon, V., Holman, T.R., "Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases", Bio. Med. Chem., 14, 4295-4301, 2006. PDF
Kenyon, V., Chorny, I., Carvajal, W., Holman, T.R., Jacobson, M. "Novel human lipoxygenase inhibitors discovered using virtual screening with homology models", J. Med. Chem., 49, 1356-1363, 2006. PDF
Ghosh, K., Thompson, A., Oh, E., Shi, X., Goldbeck, R., Zhiwu, Z.,Vulpe, C., Holman, T.R., " Spectroscopic and Biochemical Characterization of Yeast Dap1p and Mouse PGRMC1 as Novel 5-Coordinate Heme Proteins", Biochemistry, 44, 16729-16736, 2005 . PDF
Cichewicz, R. H.,Clifford, L. J..Lassen, P. R..Cao, X.,Freedman, T. B.,Nafie, L. A.,Deschamps, J. D.,Kenyon,,V. A.,Flanary, J. R.,Holman, T. R.,Crews, P., "Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis", Bioorg. Med. Chem., 13, 5600-5612, 2005 . PDF
R.V. Ohri, A.T. Radosevich, K.J. Hrovat, C. Musich, D. Huang, T.R. Holman, F.D. Toste, "A Re(V)-Catalyzed C-N Bond-Forming Route to Human Lipoxygenase Inhibitors", Organic Letters, 7, 2501-2504, 2005. PDF
V.C. Ruddat, S. Whitman, R.D. Klein, S.M. Fischer, T.R. Holman, "Evidence for Downregulation of Calcium Signaling Proteins in Advanced Mouse Adenocarcinoma", Prostate, 64, 128-138, 2005 . PDF
Robert H. Cichewicz, Victor A. Kenyon, Stephanie Whitman, Nancy M. Morales, Joanne F. Arguello, Theodore R. Holman, Phillip Crews, "Redox Inactivation of Human 15-Lipoxygenase by Marine-Derived Meroditerpenes and Synthetic Chromanes: Archetypes for a Unique Class of Selective and Recyclable Inhibitors", J.A.C.S., 126, 14910-14920, 2004 . PDF
V.C.Ruddat, R. Mogul, I. Chorny, C. Chen, N. Perrin, S.Whitman, V. Kenyon, M.P. Jacobson, C. Bernasconi and T.R.Holman, "Trp500 and Arg707 Define Product and Substrate Active Site Binding in Soybean Lipoxygenase-1", Biochemistry , 43, 13063-13071, 2004 . PDF
J.T. Gautshi, S. Whitman, T.R. Holman and P. Crews "An Analysis of Phakellin and Oroidin Structures Stimulated by Further Study of an Agelas Sponge", J. Nat. Prod. , 67, 1256-1261, 2004 . PDF
E.Segraves, R. Shah, N. Segraves, T. Johnson, S. Whitman, J. Sui, V. Kenyon, R. Cichewicz, P. Crews, T.R. Holman, "Probing the Activity Differences of Simple and Complex Brominated Aryl compounds against 15-Soybean, 15-Human and 12-Human Lipoxygenase", J. Med. Chem. , 47, 4060-4065, 2004 . PDF
K. Ghosh, A. Eroy-Reveles, T.R. Holman, M. Olmstead, P.K. Mascharak, "Reactions of NO with Mn(II) and Mn(III) Center Coordinated to Carboxamido Nitrogen: Synthesis of a Manganese Nitrosyl with Photolabile NO", Inorganic Chemistry , 43, 2988-2997, 2004 . PDF
M.-T. Gutierrez-Lugo, J.D. Deschamps, T.R. Holman, E. Suarez, B.N. Timmermann, Lipoxygenase Inhibition of Anadanthoflavone, a new flavonoid from Anadenantherra colubrine (Vell.) Brenan var cebil (Griseb.) Alschul, Planta Medica , 70 , 263-265, 2004. PDF
G. Schenk, M.L.Neidig, J.Zhou, T.R.Holman and E.I.Solomon, Spectroscopic Characterization of Soybean Lipoxygenase. 1 Mutants: the Role of Second Coordination Sphere Residues in the Regulation of Enzyme Activity, Biochemistry , 42 , 7294-7302, 2003 . PDF
E.Segraves, T.R. Holman, Kinetic Investigations of the Rate-Limiting Step in Human 12- and 15-Lipoxygenase, Biochemistry , 42 , 5236-5243, 2003. PDF
V.C.Ruddat, S.Whitman, T.R.Holman and C.F.Bernasconi, Stopped-Flow Kinetic Investigations of the Activation of Soybean Lipoxygenase-1 and the Influence of Inhibitors on the Allosteric Site, Biochemistry , 42 , 4172-4178, 2003. PDF
T.Amagata, S.Whitman, T.Johnson,C.C. Stessmann, C.Loo, E.Lobkovsky, J.Clardy, P.Crews, and T.R.Holman, Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-human, 15-human, and 15-soybean Lipoxygenases, J. Nat. Prod. , 66 , 230-235, 2003. PDF
S. Whitman , M. Gezginci, B. Timmerman and T. Holman, Structure-Activity Relationship of Norihydroguaiaretic Acid Inhibitors toward Soybean, 12-Human, and 15-Human Lipoxygenase, Journal of Medicinal Chemistry , 45 , 2659-2661, 2002. PDF
J. Carroll, E. Jonsson, R. Ebel, M. Hartman, T. R. Holman and Phillip Crews, Probing Sponge-Derived Terpenoids for Human 15-Lipoxygenase Inhibitors, Journal of Organic Chemistry , 66 , 6847-6851, 2001. PDF
D. Tomchick, P. Phan, M. Cymborowski, W. Minor and T. R. Holman, Structural and Functional Characterization of Second-Coordination Sphere Mutants of Soybean Lipoxygenase-1, Biochemistry 40 , 7509-7517, 2001. PDF
R. Mogul and T. R. Holman, Inhibition Studies of Soybean and Human 15-Lipoxygenases with Long Chain Alkenyl Sulfate Substrates, Biochemistry 40 , 4391-4397, 2001. PDF
R. Mogul, E. Johansen, and T. R. Holman, Oleyl Sulfate Reveals Allosteric Inhibition of Soybean Lipoxygenase-1 and Human 15-Lipogenase, Biochemistry 39 , 4801-4807, 2000. PDF
E. Lewis, E. Johnson, and T. R. Holman, Large Competitive Kinetic Isotope Effects in Human 15-Lipoxygenase Catalysis Measured by a Novel HPLC Method, J. Am. Chem. Soc. 121 , 1395-1396, 1999.PDF
T. R. Holman, J. Zhou, and E. I. Solomon, Spectroscopic and Functional Characterization of Ligand Coordination Mutations of Soybean and Human 15-Lipoxygenase, J. Am. Chem. Soc. 120 , 12564-12572, 1998. PDF